Monday, 24 April 2017

Cytoxicity of Gold NP over Mouse Gastric Stem Cells: Short Commentary

Raman spectroscopy (RS) is an emerging lased based optical technique exploited extensively in the field of bio-medical research.
Mouse Gastric Stem Cells

The principle involved in RS is when a monochromatic light is incident on an analyte, originates scattered light after interacting with sample and a small fraction of the incident light will be in elastically scattered and is used to construct Raman spectrum.

It is a more powerful tool to characterize any biological system, diagnose disease in tissue, cells and to understand the basics in biology.

Wednesday, 19 April 2017

Effect of Selective Laser Trabeculoplasty in Glaucoma Patients with High or Low Central Corneal Thickness

Laser Trabeculoplasty

In 1997, Latina et al. launched selective laser trabeculoplasty (SLT) as a new treatment to lower intraocular pressure. Since then, SLT has proven to be efficient and its use has become widespread. Several studies have been performed to investigate which factors influence the outcome of SLT.

Up to now, only higher pre-laser IOP seems to be correlated to higher IOP lowering effect of the SLT; other factors like race 6, trabecular meshwork pigmentation, number and type of previously used anti-glaucoma medications, previous laser and phakic or pseudophakic eyes showed no impact on SLT efficiency.

Shazly et al. examined whether central corneal thickness had influence on SLT outcome and suggested that thinner corneas gave better IOP reduction after SLT

Monday, 10 April 2017

Hepatocyte Growth Factor as an Indicator of Reduced Handgrip Strength among Non-Overweight Hypertensive Elderly Men

Handgrip strength is an efficient tool to evaluate the loss of skeletal muscle mass and function since handgrip strength is regarded as a predictor of old age disability.  Common agerelated disease including hypertension and sacropenia are reported to be exacerbated by disruption of the micro-vascular endothelium and impair blood flow by increasing in age-related inflammatory agents. Previously we reported positive association between handgrip strength and circulating CD34-positive cells in hypertensive men but not in non-hypertensive men. This study indicates that vascular maintenance attributed by circulating CD34-positive cells might compensate for the disturbed handgrips strength triggered by hypertension induced vascular damage. PDF LINK
Handgrip strength is an efficient tool to evaluate the loss of skeletal muscle mass and function since handgrip strength is regarded as a predictor of old age disability.

Common agerelated disease including hypertension and sacropenia are reported to be exacerbated by disruption of the micro-vascular endothelium and impair blood flow by increasing in age-related inflammatory agents.

Previously we reported positive association between handgrip strength and circulating CD34-positive cells in hypertensive men but not in non-hypertensive men. This study indicates that vascular maintenance attributed by circulating CD34-positive cells might compensate for the disturbed handgrips strength triggered by hypertension induced vascular damage.


Monday, 3 April 2017

Mindfulness-Based Intervention: A Culturally Adaptable Intervention In Clinical Psychology

Clinical Psychology

Mindfulness is defined as nonjudgmental acceptance and paying attention in specific way to current thoughts and emotions. The concept of mindfulness is directly inspired by the Buddhist tradition, but it is not considered a religious practice.

It is also not constrained to the Buddhist tradition. Mindfulness-based interventions were derived from the concept of mindfulness and were reported to be effective in relieving pain and alleviating anxiety and depression in different population.

Recently, most studies about mindfulness were reported from Westen literature, and little evience was available regarding using mindfulness in Arab population. As I was a psychiatric nurse, my publications focused on the advanced roles of nurses.

Tuesday, 21 March 2017

Effect of Iron Deficiency Anaemia on Haemoglobin A1c Levels

Iron Deficiency Anaemia
Iron deficiency anaemia is the most common form of anaemia in India. Haemoglobin A1c (HbA1c) is used in diabetic patients as an index to reflect glucose levels of the previous 3 months.

Like blood sugar levels, HbA1c levels are also affected by presence of variant haemoglobin, haemolytic anaemia, nutritional anaemias, uremia, pregnancy and acute blood loss. However, reports on the effects of iron deficiency anaemia on HbA1c levels are inconsistent.

We conducted a study to analyze the effects of iron deficiency anaemia on HbA1c levels and to assess whether treatment of iron deficiency anaemia affects HbA1c levels.


Tuesday, 14 March 2017

Effect of Iron Deficiency Anaemia on Haemoglobin A1c Levels

Iron Deficiency Anaemia

Iron deficiency anaemia is the most common form of anaemia in India. Haemoglobin A1c (HbA1c) is used in diabetic patients as an index to reflect glucose levels of the previous 3 months. Like blood sugar levels, HbA1c levels are also affected by presence of variant haemoglobin, haemolytic anaemia, nutritional anaemias, uremia, pregnancy and acute blood loss. However, reports on the effects of iron deficiency anaemia on HbA1c levels are inconsistent. We conducted a study to analyze the effects of iron deficiency anaemia on HbA1c levels and to assess whether treatment of iron deficiency anaemia affects HbA1c levels.

Methods: Fifty patients confirmed to have iron deficiency anaemia were enrolled in the study. HbA1c levels of them were measured both at baseline and after 3 months of treatment of iron deficiency. These values were also compared with those in the control population.

Results: The mean baseline HbA1c level in anaemic patients (6.60) was significantly higher than that of controls (5.48). However, after 3 months of treatment, significant decline from 6.60 to 5.74 was found in HbA1c levels.

Tuesday, 18 October 2016

Mysterious Leukocytosis in Sickle Cell Disease

Patients with sickle cell disease (SCD) can present with both acute and chronic complications. Acute complications include acute chest syndrome, multisystem organ failure syndrome, aplastic crisis, splenic sequestration, hyper-hemolysis crisis, thrombotic thrombocytopenic purpura-like syndrome, acute stroke and hepatic sequestration or acute intrahepatic cholestasis.

Mysterious Leukocytosis in Sickle Cell Disease
SCD patients often have complications related to vasoocculsive disease including avascular necrosis of the femoral or humeral head, chronic pain and chronic venous ulcers.

Chronic hemolytic anemia, pulmonary hypertension and secondary hemochromatosis due to transfusion related iron overload are just some of the chronic manifestations of SCD.