Patients with sickle cell disease (SCD) can present with both
acute and chronic complications. Acute complications include acute chest
syndrome, multisystem organ failure syndrome, aplastic crisis, splenic
sequestration, hyper-hemolysis crisis, thrombotic thrombocytopenic purpura-like syndrome, acute stroke and hepatic
sequestration or acute intrahepatic cholestasis.
SCD patients often
have complications related to vasoocculsive disease including avascular
necrosis of the femoral or humeral head, chronic pain and chronic venous
ulcers.
Chronic hemolytic
anemia, pulmonary hypertension and secondary hemochromatosis due to transfusion
related iron overload are just some of the chronic manifestations of SCD.
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