Effect of Iron Deficiency Anaemia on Haemoglobin A1c Levels

Iron deficiency anaemia is the most common form of anaemia in India. Haemoglobin A1c (HbA1c) is used in diabetic patients as an index to reflect glucose levels of the previous 3 months.

Like blood sugar levels, HbA1c levels are also affected by presence of variant haemoglobin, haemolytic anaemia, nutritional anaemias, uremia, pregnancy and acute blood loss. However, reports on the effects of iron deficiency anaemia on HbA1c levels are inconsistent.

We conducted a study to analyze the effects of iron deficiency anaemia on HbA1c levels and to assess whether treatment of iron deficiency anaemia affects HbA1c levels.

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Effect of Iron Deficiency Anaemia on Haemoglobin A1c Levels

Iron deficiency anaemia is the most common form of anaemia in India. Haemoglobin A1c (HbA1c) is used in diabetic patients as an index to reflect glucose levels of the previous 3 months. Like blood sugar levels, HbA1c levels are also affected by presence of variant haemoglobin, haemolytic anaemia, nutritional anaemias, uremia, pregnancy and acute blood loss. However, reports on the effects of iron deficiency anaemia on HbA1c levels are inconsistent. We conducted a study to analyze the effects of iron deficiency anaemia on HbA1c levels and to assess whether treatment of iron deficiency anaemia affects HbA1c levels.

Methods: Fifty patients confirmed to have iron deficiency anaemia were enrolled in the study. HbA1c levels of them were measured both at baseline and after 3 months of treatment of iron deficiency. These values were also compared with those in the control population.

Results: The mean baseline HbA1c level in anaemic patients (6.60) was significantly higher than that of controls (5.48). However, after 3 months of treatment, significant decline from 6.60 to 5.74 was found in HbA1c levels.

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Mysterious Leukocytosis in Sickle Cell Disease

Patients with sickle cell disease (SCD) can present with both acute and chronic complications. Acute complications include acute chest syndrome, multisystem organ failure syndrome, aplastic crisis, splenic sequestration, hyper-hemolysis crisis, thrombotic thrombocytopenic purpura-like syndrome, acute stroke and hepatic sequestration or acute intrahepatic cholestasis.

SCD patients often have complications related to vasoocculsive disease including avascular necrosis of the femoral or humeral head, chronic pain and chronic venous ulcers.

Chronic hemolytic anemia, pulmonary hypertension and secondary hemochromatosis due to transfusion related iron overload are just some of the chronic manifestations of SCD.

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